Silvia Cappello, PhD
RICHARD DOLL PROFESSOR OF EPIDEMIOLOGY AND MEDICINE; DIRECTOR, TRANSLATIONAL EPIDEMIOLOGY UNIT
David Hunter studied medicine at the University of Sydney, before moving to Harvard University for 33 years where he was the Vincent L. Gregory Professor of Cancer Prevention. He is the Richard Doll Professor of Epidemiology and Medicine, and director of the Harvard-Oxford Program in Epidemiology. His early research was on HIV transmission in East Africa, and subsequently he was involved in collaborative studies of nutrition and HIV pathogenesis, while also studying diet and cancer etiology in large scale prospective studies and founding the Pooling Project of Prospective Studies of Diet and Cancer.
As Director of the Harvard Center for Cancer Prevention he developed a sample handling and genotyping laboratory to explore genetic associations with cancer, and gene-environment interactions. He founded the Program in Genetic Epidemiology and Statistical Genetics at Harvard. He was co-chair of the steering committee of the NCI Breast and Prostate Cancer Cohort Consortium (BPC3) between 2003 and 2012, was co-director of the NCI Cancer Genetic Susceptibility Markers project focused on genome-wide association studies, and was an Eminent Scholar at the NCI between 2004 and 2009.
From 2009-2016 he was Dean for Academic Affairs at the Harvard TH Chan School of Public Health, and in 2015-2016 he was Acting Dean. He is one of about 3000 “highly cited researchers” worldwide according to Thomson-Reuters.
Dr. Matthew Hurles studied Biochemistry at Oxford University, before gaining a PhD in Genetics from the University of Leicester and establishing the Genomic Mutation and Genetic Disease group at the Wellcome Trust Sanger Institute in 2003. From 2003-2011, Matt led major initiatives to characterise structural variation in the human genome, and integrate this knowledge into disease and population genetic studies. His current research interests are in the genetic causes of severe developmental disorders, pre- and post-natally, many of which are caused by new germline mutations, and the causes of variation in germline mutation rates. Matt has had leadership roles in the 1000 genomes project and the UK10K project, and is the principal investigator of the Deciphering Developmental Disorders (www.ddduk.org) and Prenatal Assessment of Genomes and Exomes (https://www.pageuk.org/) projects. These projects have discovered tens of novel disorders, diagnosed thousands of patients and lead to a transformation in genetic diagnostic practice. This lead to Matt co-founding a start-up company, Congenica Ltd, to develop software to provide sustainable genetic diagnostic services to the NHS and other healthcare providers. Matt is the scientific lead of DECIPHER (https://decipher.sanger.ac.uk/), which is driving open data sharing to improve genetic diagnostic interpretation. Matt is also Associate Director of the Health Data Research UK site in Cambridge, with the aim of integrating genomic and clinical data at an unprecedented scale and resolution. His group also generates and characterises cellular and animal models of developmental disorders, to understand pathophysiological mechanisms and identify therapeutic opportunities. Matt gave the Genetics Society Balfour Lecture in 2009 and the Royal Society Crick Lecture in 2013. In 2017, Matt became the Head of the Human Genetics programme at the Sanger Institute and was elected as a Fellow of the Academy of Medical Sciences. In 2019, Matt was elected as a Fellow of the Royal Society.
Nenad Sestan, MD, PhD, is the Harvey and Kate Cushing Professor of Neuroscience, Professor of Comparative Medicine, of Genetics and of Psychiatry, and a member of the Kavli Institute for Neuroscience at the Yale School of Medicine. He obtained his M.D. from the University of Zagreb and his Ph.D. in neurobiology from Yale University. Nenad Sestan’s research has been concerned with the molecular and cellular mechanisms that control the formation of neural circuits within the developing cerebral cortex of humans and other mammals. His laboratory also studies how neural circuit development was modified during evolution and may become compromised in neuropsychiatric and neurodevelopmental disorders.
Nenad Sestan is the recipient of several international honors and awards, including memberships in the National Academy of Medicine and Croatian Academy of Sciences and Arts, Constance Lieber Prize, Krieg Cortical Discoverer Prize, NARSAD Distinguished Investigator Award, McDonnell Scholar Award and Krieg Cortical Scholar. He has been a member of the BrainSpan and PsychENCODE consortia.