2024 Plenary Speakers

Henriette "Jetty" Raventós, MD, PhD

Henriette "Jetty" Raventós, MD, PhD

Professor, University of Costa Rica

Chair of Diversity Panel

Biography

Prof. Henriette Raventós is a ISPG Board of Directors member and directs the University of Costa Rica neuropsychiatric genetics research group. During her career, she has advocated for underrepresented groups in science, aiming to increase global representation and reduce inequalities in psychiatric genetic research.

Comfort "Ofure" Okoh

Comfort "Ofure" Okoh

Max Planck Institute of Psychiatry

Co-Chair of Diversity Panel

Biography

Ofure Okoh is a PhD student at the Max Planck Institute for Psychiatry, Munich. She is affiliated with the Max Planck School of Cognition, Leipzig, and the Ludwig Maximilians University Munich. In her current research, she seeks to elucidate the impact of risk variants on the SLC6A15 gene in a stress context using enhancer screening tools and cellular models. Her research aims to understand how distortions in the expression of this gene can lead to the emergence of psychiatric phenotypes like insomnia, including its connection to cognitive deficits. She serves as a communication and outreach liaison to the Africa Diversity group of the Psychiatric Genomics Consortium, a member of the Black in Neuro and ALBA Organizations. She hopes to use her work to establish an international scientific collaboration between Africa and other parts of the world, to improve the management of psychiatric disorders.

Diego Luiz Rovaris

Diego Luiz Rovaris

Assistant Professor, University of São Paulo

Molecular Psychiatry in the Diverse Landscape of Latin America

Biography

Prof. Diego Luiz Rovaris is a Tenured Assistant Professor at the Institute of Biomedical Sciences, University of São Paulo (ICB-USP), Brazil. With over 13 years of experience in Molecular Psychiatry, his research focuses on ADHD and related phenotypes. He leads the Laboratory of Physiological Genomics of Mental Health at ICB-USP, investigating how environmental factors interact with genomics and epigenomics to affect the risk and progression of mental disorders with varying heritability, such as major depressive disorder and ADHD. He is the scientific head of the Brazilian Research Network on Adult ADHD and co-leads the ADHD working group of the Latin American Consortium (LAGC). He is the Principal Investigator of CONNECT-ADHD (comprehensive exploration of the CONNECTion between ADHD and educational attainment in contrasting environments), a project involved in the Ancestral Populations Network of the National Institute of Mental Health. Committed to promoting diversity, he aims to increase the representation of non-European individuals in genomics collaborations in psychiatry and to enhance the participation of scientists from low- and middle-income countries (LMICs) in relevant scientific forums.

Aïcha Dahdouh, MD, PhD

Aïcha Dahdouh, MD, PhD

Professor, Service Hospitalo-Universitaire, GHU Paris Psychiatrie and Neurosciences

Substance Use Disorders in Algeria: Between Clinical Practice, Official Figures and Research Opportunities

Biography

Prof. Aïcha Dahdouh is a Professor of Psychiatry in Algeria and head of the Psychiatry-Addictology Department at the Faculty of Medicine in Oran, University Oran 1 Ahmed Benbella. Aïcha currently works in the Department of Psychiatry and Neuroscience at GHU Paris F-75014, as an Associate Practitioner. Her past and present research focuses on the impact of social practices on the onset and development of mental disorders. Her doctoral thesis is in medical sciences, and it is entitled “Search for Genetic Variants of Schizophrenia and Bipolar Disorders in Consanguineous Families in Algeria". A number of particularly relevant genetic results have emerged from this work, and are currently in the process of publication. Aïcha is currently working on addictions among young people in Algeria and associated factors: psychiatric comorbidities and social risk factors (violence against women, maternal depression, childhood abuse and trauma...). She collaborates with the PGC Africa working group on Psychosis and substance use disorders research projects in Africa.

Weihua Yue, MD

Weihua Yue, MD

Professor, Peking University Sixth Hospital & Institute of Mental Health

Exploration on Genetic Susceptibility of Schizophrenia in the Chinese Han Population

Biography

Prof. Weihua Yue is a Professor of Psychiatry and the Deputy Director of Peking University Sixth Hospital & Institute of Mental Health; National Clinical Research Center for Mental Disorders (Peking University). Beijing, 100191, P.R. China She has been supported by the National Science Fund for Distinguished Young Scholars and Outstanding Young Scholars, National Key Research and Development Program, etc. Her group secured the Second Prize in Natural Science, awarded by the Ministry of Education. The group focuses on genetic research of schizophrenia. She has published representative articles in Nat Genet (2019, 2011), Lancet Psychiatry, Cell Discov, Mil Med Res, Mol Psychiatry, Biol Psychiatry, Psychiatry Clin Neurosci, and JAMA Netw Open to name a few.

Sanjeev Jain, MD

Sanjeev Jain, MD

Professor, National Institute of Mental Health & Neurosciences

The Diversity Dividend: Exploring Psychiatric Genetics in the Large and Diverse Population of India

Biography

Prof. Sanjeev Jain is an Emeritus Professor at the Department of Psychiatry, Molecular Genetics Laboratory, National Institute of Mental Health and Neurosciences, Bangalore, India. His work has been enquiry into genetic mechanisms of psychoses; and the broader issues of the interfaces between psychopathology and biology. This work connects the clinic to the bench, using advanced cellular and molecular biology methods. As a lead investigator for the Accelerator program for discovery in brain disorders using stem cells (ADBs), the lab created a repository of phenotype data from carefully and comprehensively assessed participants, detailed genetic information, and created iPSC and neuronal lines. This will enable researchers to explore the genetic contributions to these syndromes using family and population-based genetics research and also interrogate the impact of this genetic variation. A Genetic Counselling and Testing Clinic (GCAT clinic) established by the lab provides molecular diagnostics for many syndromes (Huntington’s disease, ataxia, DMD etc.). His work thus looks at the epidemiology of rare variants, and their contributions to disease; as also population-based analyses, with specific reference to India.

Michael Ziller, PhD

Michael Ziller, PhD

Professor, University of Muenster Germany

Dissecting the Genetic Basis of Schizophrenia Using Functional Genomics and Pluripotent Stem Cell Models

Biography

Prof. Michael Ziller is Professor of Functional Genomics in Psychiatry in the Department of Mental Health at the University of Muenster, Germany. He is a trained physicist and bioinformatician and obtained Diploma degrees in both areas in 2010 from the University of Tuebingen, Germany. He pursued his doctoral work at the Department of Stem Cell Biology and Regenerative Medicine at Harvard University, receiving his PhD in 2014. From 2016-2021, he was a Principal Investigator at the Max-Planck-Institute of Psychiatry, Germany before being appointed full Professor in Muenster. His work is focused on understanding the molecular and cellular basis of psychiatric disorders that arises from the complex interplay of common and rare genetic risk factors. To this end, his group combines statistical genetic approaches, induced pluripotent stem cell based personalized disease models, functional genomics and high-content screening paradigms. Ultimately, his group seeks to disentangle the complex genotype-phenotype relationships in psychiatric disorders by integrating new genetic risk-scores with cellular in vitro based endophenotypes to bridge the scales and link them to patient-level intermediate phenotypes.

Jian Yang, PhD

Jian Yang, PhD

Professor, Westlake University

From Genetic Associations to Genes and Cellular Contexts for Human Complex Traits

Biography

Dr. Jian Yang is a Professor of Statistical Genetics at the School of Life Sciences, Westlake University, China. He received his PhD in 2008 from Zhejiang University, China, before undertaking postdoctoral research at the QIMR Berghofer Medical Research Institute in Australia (2008-2011). He moved to The University of Queensland (UQ), Australia, as a Research Fellow in 2012 and was reappointed as a Senior Research Fellow and Group Leader in January 2014. He was promoted to be an Associate Professor in December 2014, and then a Professor in January 2017 at UQ. He joined Westlake University in 2020. His primary research interests are focused on understanding the genomic variations among individuals within and between populations and the links of DNA variations and modifications to phenotypes and diseases.

Hyun Soo Shawn Je, PhD

Hyun Soo Shawn Je, PhD

Associate Professor, Duke-NUS Medical School Singapore

Modelling Neural Disorders Using Human Pluripotent Stem Cells

Biography

Prof. Shawn Je is currently a tenured Associate Professor in the Neuroscience and Behavioral Disorders Program at Duke-NUS Medical School in Singapore and Director of the SingHealth Advanced Imaging Centre. He received his B.S. from KAIST, M.S. from the University of Michigan, Ann Arbor, and his Ph.D. in Neuroscience and Genetics from the National Institutes of Health (NIH) Graduate Partnership Program through the George Washington University Medical School. He then completed a Howard Hughes Medical Institute (HHMI)/ Duke University Medical School postdoctoral fellowship. He joined the Duke-NUS Medical School as an Assistant Professor in late 2010 and received his tenure in 2017. He received the Scientist of the Year Award from Ministry of Science and ICT, Korea. His research focuses on the molecular and cellular mechanisms underlying neurological and psychiatric disorders.

Andrew McIntosh, MD

Andrew McIntosh, MD

Professor, University of Edinburgh

Advancing Depression Genetics and Making it Useful

Biography

Dr. Andrew McIntosh is a Professor of Psychiatry at the Centre for Clinical Brain Sciences, University of Edinburgh and a consultant psychiatrist working in the NHS. He co-chairs the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) and is the director of the newly funded UK Mental Health Platform, an initiative to promote data sharing, collaboration and the involvement of both industry and people with lived experience in research. His research focussed on identifying the causes and consequences of depression using genomic approaches and by linking to large and routinely collected health datasets.

Jehannine Austin, PhD

Jehannine Austin, PhD

Professor, University of British Columbia

IDEA Committee Plenary

 

Practical and Realistic Strategies for Being an Effective DEI Ally: Justice-Based Approaches to Academic Authorship, Publishing, Mentoring and Sponsorship

Biography

Dr. Jehannine Austin is a Professor in Psychiatry & Medical Genetics at the University of British Columbia. Jehannine is a board certified genetic counsellor, and their research work involves studying how to improve access to genetics services for people who have historically been marginalized, and working to ensure that those services are safe and effective. They founded the world’s first specialist psychiatric genetic counselling service (which won an award for its impact on patient outcomes), and in addition to peer-reviewed publications, has written a book, and won awards for teaching, leadership, and research. Jehannine is a Fellow of the Canadian Academy of Health Sciences, Editor in Chief of the Journal of Genetic Counseling and president elect of ISPG.

Brenda Penninx, PhD

Brenda Penninx, PhD

Professor, Amsterdam UMC, Vrije Universiteit

Using (Gen)omics to Disentangle Depression’s Heterogeneity

Biography

Prof. Brenda Penninx is Professor in Psychiatric Epidemiology at the Department of Psychiatry of the Amsterdam UMC, Vrije Universiteit in the Netherlands. Her focus is on cross-disciplinary depression research which integrates psychiatry, psychology, neuroimaging, genomics, psychoneuroendocrinology, sociology and behavioural medicine. She founded the multi-site, longitudinal Netherlands Study of Depression and Anxiety (www.nesda.nl), an invaluable research resource for psychiatry which data have been used in >100 PhD-theses and >900 publications. Her work is exemplary in transforming and enhancing the value of longitudinal cohort studies to better understand the multi-nature origin and longitudinal trajectories of stress-related disorders. Penninx uses cohort data to better understand the role of (interactions between) psychosocial, neurobiological and genetic factors in the etiology and course of depression disorder, and to disentangle the large heterogeneity of depressive disorder. For this, she integrates big-data ‘omics’ including genomics in her studies. Her research is funded through various national, EU- and NIH-grants, and she has supervised over 70 PhD students in obtaining their PhD-degree. In 2016, Penninx was elected member of the Royal Dutch Academy of Sciences and Arts, of which she currently serves as Vice President.